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The Science Behind the Miracle Hormone Big Pharma Doesn’t Want You to Understand

Clinical Studies Support the Ingredients in Beyond GLP-1

Weight Loss Management

Brain cognition enhancement

Vitality & Mood Booster

What We Found

Each ingredient in Beyond GLP-1 was chosen because it’s been shown in clinical studies to impact the areas that matter most—metabolism, appetite control, mood, gut health, and hormonal balance.

Read The Studies

Not Just a Trend—A Formula Backed by Real Science

Our breakthrough formulation is backed by ingredient-level science—proven to transform health by targeting the gut, metabolism, and hormones.Studies on our hero ingredients, like Berberine, Cinnamon, and Moringa, show real results in blood sugar balance, fat metabolism, and appetite control—starting with the gut and radiating outward.

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The Science behind our ingredients

Berberine HCl

Berberine (350 mg): Multiple clinical trials support berberine’s metabolic benefits. In women with PCOS, a 3-month RCT (500 mg twice daily) found berberine improved body composition and hormones: it reduced weight and waist size and lowered testosterone, with outcomes comparable to metformin​pmc.ncbi.nlm.nih.gov ​pmc.ncbi.nlm.nih.gov. Berberine also raised SHBG and improved insulin sensitivity in these women, indicating better hormonal balance. More broadly, a meta-analysis of 12 RCTs in obese/diabetic adults showed berberine led to significant weight loss – about 2.0 kg more than placebo on average​pubmed.ncbi.nlm.nih.gov. Participants taking ~500 mg 2–3× daily for 3 months saw reductions in BMI and waist circumference as well​pubmed.ncbi.nlm.nih.gov. These studies illustrate berberine’s ability to mimic some GLP-1 drug effects (improving glycemic control and aiding weight loss) via insulin-sensitizing and appetite-suppressing actions. The evidence is particularly strong in insulin-resistant populations (e.g. PCOS, type 2 diabetes).

Primary Study

Inulin is a type of soluble fiber derived from plants like chicory root, asparagus, and garlic. It serves as a prebiotic, feeding beneficial gut bacteria and supporting digestive health. Inulin also helps in slowing digestion, promoting a feeling of fullness, and potentially aiding in weight management.

Gymnema Sylvestre

Gymnema Sylvestre (175 mg): Gymnema is an herb famed for reducing sweet cravings and supporting glucose control. Human trials indicate it can aid weight management. In a 12-week double-blind trial of 24 adults with metabolic syndrome, taking 600 mg/day of Gymnema sylvestre extract resulted in significantly greater weight loss than placebo​pubmed.ncbi.nlm.nih.gov. The Gymnema group lost about 3.4 kg (from ~81.3 to 77.9 kg) versus ~0.5 kg in controls, alongside a drop in BMI​pubmed.ncbi.nlm.nih.gov. Notably, Gymnema users also saw improvements in triglycerides and VLDL, without adverse effects on insulin secretion​pubmed.ncbi.nlm.nih.gov. These results align with Gymnema’s known actions: its gymnemic acids can block sugar taste receptors and slow intestinal sugar absorption, leading to reduced calorie intake. By curbing sweet cravings and post-meal glucose spikes, Gymnema supplementation helps support appetite control and modest weight loss. (Most studies use 400–600 mg/day of extract; the 175 mg in our context likely refers to a concentrated form.)

Primary Study

Inulin is a type of soluble fiber derived from plants like chicory root, asparagus, and garlic. It serves as a prebiotic, feeding beneficial gut bacteria and supporting digestive health. Inulin also helps in slowing digestion, promoting a feeling of fullness, and potentially aiding in weight management.

L-Carnitine

L-Carnitine (175 mg): L-Carnitine is an amino-acid derivative involved in fat metabolism and energy production. Research suggests supplementation can produce modest weight loss and energy benefits, especially in those who are carnitine-deficient or overweight. A meta-analysis of 9 clinical trials (primarily overweight adults) found L-carnitine users lost about 1.1 kg more weight than placebo groups on average​pubmed.ncbi.nlm.nih.gov. Doses in these studies ranged ~1–3 g/day over 8–24 weeks. Carnitine is also notable for its effects on the brain: a systematic review of 12 RCTs using acetyl-L-carnitine (ALC) found it significantly improved mood and mental clarityin patients with depression, with efficacy comparable to standard antidepressants (particularly in older adults)​pubmed.ncbi.nlm.nih.gov​pubmed.ncbi.nlm.nih.gov. In those trials, doses ~1–3 g/day ALC for 6–12 weeks led to reduced depressive symptoms and fatigue. Together, these findings indicate L-carnitine can modestly enhance fat burning (leading to weight/fat loss) and may improve energy levels and cognitive function – making it a valuable addition for both weight management and brain health. (The 175 mg dose here is lower; often such formulas include acetyl-L-carnitine for cognitive benefits in addition to metabolic support.)L-Carnitine (175 mg):

Primary Study

Inulin is a type of soluble fiber derived from plants like chicory root, asparagus, and garlic. It serves as a prebiotic, feeding beneficial gut bacteria and supporting digestive health. Inulin also helps in slowing digestion, promoting a feeling of fullness, and potentially aiding in weight management.

Green tea extract

Green Tea Extract (EGCG) (225 mg): Green tea catechins, especially EGCG, are well-documented to assist with weight control and antioxidative support. A 2023 meta-analysis of 59 RCTs (3,802 participants) concluded that green tea extract (GTE) supplementation produces a significant, though modest, reduction in body weight and fat percentage​nutraingredients-usa.com. Across studies (typical dose 300–800 mg EGCG/day), GTE users saw lower body mass index (BMI) and body fat, and improved antioxidant status, compared to placebo​nutraingredients-usa.com. One analysis noted GTE resulted in an extra ~1.4 kg of weight loss versus placebo in overweight adults​journals.lww.com​nutraingredients-usa.com. The combination of EGCG + caffeine in green tea likely boosts metabolic rate and fat oxidation slightly. Beyond weight, green tea polyphenols have been shown to enhance brain function (EGCG can improve attention and working memory in some studies) and mood (the amino acid L-theanine in green tea has calming effects). In overweight women, 6 weeks of green tea extract raised adiponectin (a hormone that improves insulin sensitivity) and lowered LDL cholesterol​bmccomplementmedtherapies.biomedcentral.com, reflecting metabolic and hormonal benefits. Overall, taking EGCG-rich green tea extract can modestly increase calorie burning and fat loss while also providing antioxidant and cognitive benefits.

Primary Study

Inulin is a type of soluble fiber derived from plants like chicory root, asparagus, and garlic. It serves as a prebiotic, feeding beneficial gut bacteria and supporting digestive health. Inulin also helps in slowing digestion, promoting a feeling of fullness, and potentially aiding in weight management.

Cinnamon Extract

Cinnamon Extract (90 mg): Cinnamon is a popular herbal supplement for blood sugar regulation – which is highly relevant for weight and hormonal health. In women with PCOS (who often have insulin resistance), a randomized trial using 1.5 g/day of cinnamon for 12 weeks showed improved insulin sensitivity and menstrual regularity​pmc.ncbi.nlm.nih.gov​pmc.ncbi.nlm.nih.gov. A systematic review of RCTs in PCOS found cinnamon supplementation led to significant weight reduction and lower insulin resistance, with effects comparable to metformin in some cases​sciencedirect.com​pharmacytimes.com. For example, one trial reported cinnamon brought about similar drops in body weight and fasting insulin as metformin did over 8 weeks​pmc.ncbi.nlm.nih.gov. Outside of PCOS, cinnamon has demonstrated benefits in type 2 diabetics – a meta-analysis noted it lowers fasting glucose, HbA1c, and even body weight modestly. The active polyphenols (like cinnamaldehyde) appear to improve cellular glucose uptake and digestion. Clinically, cinnamon extract can help curb blood sugar spikes, reduce cravings, and over time support mild weight loss. The dose in our formula (90 mg) likely refers to a concentrated extract equivalent to a larger amount of cinnamon powder. Importantly, cinnamon’s hormone-balancing effect (by improving insulin function) may aid women with PCOS in losing weight and regulating cycles​pharmacytimes.com.

Primary Study

Inulin is a type of soluble fiber derived from plants like chicory root, asparagus, and garlic. It serves as a prebiotic, feeding beneficial gut bacteria and supporting digestive health. Inulin also helps in slowing digestion, promoting a feeling of fullness, and potentially aiding in weight management.

Turmeric Extract

Turmeric Extract (Curcumin) (130 mg): Curcumin, the active compound in turmeric, is a powerful anti-inflammatory that has shown promise for metabolic and mood disorders. In a clinical trial of 60 women with PCOS, taking 500 mg curcumin daily for 12 weeks led to significant weight loss and metabolic improvements compared to placebo​pubmed.ncbi.nlm.nih.gov​pubmed.ncbi.nlm.nih.gov. The curcumin group lost ~0.8 kg on average (vs 0.2 kg in placebo) and saw reductions in BMI​pubmed.ncbi.nlm.nih.gov. More impressively, curcumin improved glycemic control – lowering fasting blood sugar by ~2.6 mg/dL and insulin by 1.16 µIU/mL, thus reducing HOMA-IR (insulin resistance index)​pubmed.ncbi.nlm.nih.gov. It also significantly lowered total and LDL cholesterol while raising “good” HDL​pubmed.ncbi.nlm.nih.gov. These effects in PCOS women indicate curcumin can help balance hormones and weight by targeting insulin resistance and dyslipidemia. In overweight populations, other studies echo these findings: a meta-analysis of 21 trials in metabolic syndrome found curcumin users had reductions in weight, waist size, and leptin (a hunger hormone), along with increased adiponectin​pmc.ncbi.nlm.nih.gov​pmc.ncbi.nlm.nih.gov. Curcumin’s anti-inflammatory action in fat tissue is thought to enhance metabolism and even mood – small trials have observed curcumin (often 500–1000 mg/day) yielding antidepressant and anti-anxiety effects in people with depression. In short, even at a modest dose, curcumin contributes to weight loss, better blood sugar, and hormone balance(particularly for women with PCOS or metabolic syndrome)​pubmed.ncbi.nlm.nih.gov​pubmed.ncbi.nlm.nih.gov. Including black pepper extract (piperine) further boosts curcumin’s bioavailability.

Primary Study

Inulin is a type of soluble fiber derived from plants like chicory root, asparagus, and garlic. It serves as a prebiotic, feeding beneficial gut bacteria and supporting digestive health. Inulin also helps in slowing digestion, promoting a feeling of fullness, and potentially aiding in weight management.

Black Pepper Extract

Black Pepper Extract (Piperine) (5 mg): Though only 5 mg, piperine plays an outsized role by enhancing the absorption and effectiveness of other ingredients (like curcumin). Piperine inhibits drug-metabolizing enzymes, which can increase bioavailability of curcumin by 20-fold. Beyond this “bio-enhancer” function, piperine itself may aid metabolism. In one 8-week trial, an herbal supplement combining curcumin with piperine led to improved insulin sensitivity and lipid levels in patients with metabolic syndrome, whereas curcumin alone was less effective​sciencedirect.com. This suggests piperine synergistically amplifies metabolic benefits. Experimental studies also indicate piperine has thermogenic properties – it can stimulate thermogenesis (heat production), potentially helping burn a few extra calories. Animal models of obesity have shown piperine downregulates genes involved in fat cell formation. In a recent clinical study in adults with fatty liver, 5 mg piperine daily for 12 weeks significantly reduced ALT liver enzymes and triglycerides, and tended to reduce waist circumference (though weight change was not dramatic)​sciencedirect.com. While human weight loss data on piperine alone are still limited, it is clear that adding black pepper extract is beneficial for making the whole formula more effective. At 5 mg, piperine is a safe inclusion to ensure the user reaps the full benefits of curcumin and other co-supplements.

Primary Study

Inulin is a type of soluble fiber derived from plants like chicory root, asparagus, and garlic. It serves as a prebiotic, feeding beneficial gut bacteria and supporting digestive health. Inulin also helps in slowing digestion, promoting a feeling of fullness, and potentially aiding in weight management.

Fenugreek Extract

Fenugreek Extract (40 mg): Fenugreek seed has a long history in blood sugar control and hormonal balance. Notably, it’s one of the few herbs studied specifically in PCOS. A recent 12-week RCT in women with PCOS compared fenugreek seed extract (1000 mg/day) to metformin. Fenugreek improved weight loss, insulin function, and ovarian health on par with metformin – women taking fenugreek experienced reductions in body weight and BMI, better menstrual regularity, and even a decrease in ovarian cyst number and size​examine.com​pmc.ncbi.nlm.nih.gov. Another trial reported fenugreek led to restored ovulation in many PCOS patients and significant improvement in hirsutism (excess hair) and hair loss symptoms​pmc.ncbi.nlm.nih.gov​pmc.ncbi.nlm.nih.gov. In that study, fenugreek also significantly lowered LDL cholesterol and was better tolerated than metformin​pmc.ncbi.nlm.nih.gov. These outcomes highlight fenugreek’s role in hormonal balancing – likely due to its phytoestrogen and fiber content that improve insulin sensitivity. Even outside of PCOS, fenugreek has been shown to curb appetite (its high soluble fiber can promote satiety) and modestly aid weight loss. For example, overweight individuals given 8 g/day of fenugreek fiber reported reduced hunger and ate fewer calories, leading to slight weight decreases in some trials. Our formula’s 40 mg extract is a concentrated dose (equivalent to a few grams of raw seed). Overall, evidence supports fenugreek for weight management and metabolic health, with particular effectiveness in women with PCOS for improving weight, mood (via improved insulin and androgen levels), and reproductive outcomes​examine.com.

Primary Study

Inulin is a type of soluble fiber derived from plants like chicory root, asparagus, and garlic. It serves as a prebiotic, feeding beneficial gut bacteria and supporting digestive health. Inulin also helps in slowing digestion, promoting a feeling of fullness, and potentially aiding in weight management.

Moringa Extract

Moringa Extract (130 mg): Moringa oleifera, known as the “miracle tree,” is rich in antioxidants, polyphenols, and nutrients. Human research on moringa for weight loss is still emerging, but early results are positive. A small study in overweight individuals found that taking 1 g of moringa leaf powder daily for 12 weeks led to a significant reduction in body weight, as well as lower blood pressure and improved cholesterol levels​itjfs.com. Specifically, participants on moringa lost on average a few pounds more than those on placebo. Another 8-week trial of a supplement containing moringa (300 mg), curry leaf and turmeric reported an impressive 10 lb weight loss in the moringa blend group, vs ~4 lb in placebo, among obese adults​loseit.com. While that result is from a multi-ingredient formula, it suggests moringa’s potential in enhancing fat loss. Mechanistically, moringa leaf is high in fiber and isothiocyanates that may improve insulin signaling and reduce fat accumulation​sciencedirect.com. It also contains vitamins and minerals that support energy and metabolism (iron, B-vitamins, etc.). Women with hormonal issues may benefit from moringa’s nutrient density; for instance, moringa has been used as a supplement in lactation and is being explored for metabolic syndrome in postmenopausal women. In summary, moringa extract appears to aid weight loss and metabolic health (with human trials showing reductions in weight, waist circumference, and cholesterol), though more research is needed. Its strong antioxidant profile also suggests benefits for inflammation and energy levels, which can indirectly improve mood and overall well-being during weight loss.

Primary Study

Inulin is a type of soluble fiber derived from plants like chicory root, asparagus, and garlic. It serves as a prebiotic, feeding beneficial gut bacteria and supporting digestive health. Inulin also helps in slowing digestion, promoting a feeling of fullness, and potentially aiding in weight management.

Lion’s Mane Extract

Lion’s Mane Extract (10:1) (130 mg): Lion’s Mane mushroom (Hericium erinaceus) is renowned for its nootropic and neuroprotective effects. It doesn’t directly cause weight loss, but it supports brain health, mood, and possibly nerve-related metabolic regulation. A landmark placebo-controlled trial in Japan showed that in older adults with mild cognitive impairment, taking 3 g/day of Lion’s Mane for 16 weeks led to significantly improved cognitive function (measured by cognitive scores) compared to placebo​pubmed.ncbi.nlm.nih.gov. The benefits (enhanced memory and mental clarity) gradually increased over the 4-month period​pubmed.ncbi.nlm.nih.gov. Notably, cognitive scores declined after the supplement was stopped, indicating Lion’s Mane was responsible. Another small trial in middle-aged women found Lion’s Mane can improve mood: women who consumed Lion’s Mane-enriched cookies for 4 weeks reported significantly lower anxiety and depression scores than those eating placebo cookies​pubmed.ncbi.nlm.nih.gov. They also noted reductions in menopausal symptoms like irritability and concentration difficulties​pubmed.ncbi.nlm.nih.gov. These effects are linked to Lion’s Mane stimulating nerve growth factor (NGF) and brain-derived neurotrophic factor, which support neural health. For our purposes, Lion’s Mane in a weight management formula helps address the “brain fog” and mood swings that sometimes accompany metabolic dysfunction or dieting. Users often report better focus and less stress eating when their brain is supported. While Lion’s Mane doesn’t impact hormones like insulin directly, by improving mental well-being it can indirectly aid consistent healthy habits. In short, Lion’s Mane extract provides a cognitive and mood boost – enhancing brain clarity, reducing anxiety/depression, and possibly improving sleep – all of which are valuable for individuals on a weight loss journey or dealing with PCOS-related mood issues.

Primary Study

Inulin is a type of soluble fiber derived from plants like chicory root, asparagus, and garlic. It serves as a prebiotic, feeding beneficial gut bacteria and supporting digestive health. Inulin also helps in slowing digestion, promoting a feeling of fullness, and potentially aiding in weight management.

Rhodiola Rosea

Rhodiola Rosea (40 mg): Rhodiola is an adaptogenic herb that helps the body resist physical and mental stress. Though 40 mg is a relatively low dose, even small amounts of Rhodiola extract (standardized to rosavins) have shown notable benefits for energy, mood, and stress reduction. A 4-week randomized trial in 60 adults suffering from burnout (stress-related fatigue) tested 576 mg/day of Rhodiola extract vs placebo. The Rhodiola group saw significant improvements in fatigue, concentration, and overall mental performance compared to placebo​pubmed.ncbi.nlm.nih.gov. They scored better on attention tasks and had lower cortisol levels upon waking (a sign of reduced stress)​pubmed.ncbi.nlm.nih.gov. Participants reported feeling less exhausted and more clear-headed. Importantly, Rhodiola’s effects on mood have been documented: a 6-week study in mild-to-moderate depression found Rhodiola (340–680 mg/day) significantly reduced depression symptoms and insomnia compared to placebo​pubmed.ncbi.nlm.nih.gov. While it was slightly less potent than a conventional antidepressant, it had far fewer side effects. These studies illustrate Rhodiola’s role in balancing stress hormones and neurotransmitters. For someone trying to lose weight or a woman with PCOS, this is valuable – Rhodiola can mitigate stress-related overeating and improve motivation to stay active. It may also help normalize adrenal cortisol rhythms that, when dysregulated, contribute to weight gain. In essence, Rhodiola rosea adds an energy and mood uplift to the supplement: users often experience less fatigue and anxiety, more stamina, and even better exercise endurance. All these can facilitate a healthier lifestyle and better weight management outcomes.

Primary Study

Inulin is a type of soluble fiber derived from plants like chicory root, asparagus, and garlic. It serves as a prebiotic, feeding beneficial gut bacteria and supporting digestive health. Inulin also helps in slowing digestion, promoting a feeling of fullness, and potentially aiding in weight management.

Glucomannan

Glucomannan (90 mg): Glucomannan is a soluble fiber from konjac root, known for its appetite suppressing and cholesterol-lowering effects. Clinical trials typically use higher doses (e.g. 3–4 g per day), but even smaller amounts contribute to daily fiber intake. Glucomannan expands in the stomach by absorbing water, promoting satiety with fewer calories. A 2020 meta-analysis of 8 RCTs in overweight individuals found that glucomannan supplementation led to a significantly greater weight loss compared to placebo​academia.edu​sciexplore.ir. Although results varied by study, on average glucomannan users lost an extra ~0.6–1.0 kg over 5–10 weeks versus controls. (One high-quality trial did not find a difference, but it was short-term and all participants were on a strict diet in both groups.) The consensus is that glucomannan can help as an adjunct for modest weight loss, especially by reducing appetite. Health authorities in Europe have authorized the claim that “3 g of glucomannan daily, in the context of an energy-restricted diet, contributes to weight loss.” Beyond weight, glucomannan improves lipid profiles – the fiber binds to bile acids, resulting in lower LDL cholesterol​bmccardiovascdisord.biomedcentral.com. It also slows glucose absorption, aiding blood sugar control (useful for diabetes/PCOS). In women with PCOS, adding viscous fiber like glucomannan may improve insulin sensitivity and gut health, indirectly supporting hormonal balance. At 90 mg, our formula’s glucomannan content is low, but likely included alongside other fibers (like fenugreek) to collectively reach an effective dose. Overall, glucomannan’s efficacy in promoting satiety and mild weight loss is well-supported, making it a staple ingredient in natural weight management products.

Primary Study

Inulin is a type of soluble fiber derived from plants like chicory root, asparagus, and garlic. It serves as a prebiotic, feeding beneficial gut bacteria and supporting digestive health. Inulin also helps in slowing digestion, promoting a feeling of fullness, and potentially aiding in weight management.

Cayenne Pepper Extract

Cayenne Pepper Extract (Capsaicin) (20 mg): Capsaicin from chili peppers is a thermogenic compound that can slightly increase metabolism and reduce appetite. Controlled studies show that consuming capsaicin (often 2–10 mg of capsaicinoids per dose, as in a spicy meal or supplement) can raise energy expenditure by about 50–70 calories per day​mdpi.comand encourage people to eat less at subsequent meals. A meta-analysis of 13 trials in overweight individuals concluded that capsaicin supplementation produced a significant, albeit modest, reduction in body weight and waist circumference compared to placebo​nature.com​cambridge.org. The average extra weight loss was on the order of 0.5 kg over a few months – modest but meaningful as a supportive aid​nature.com. In one study, 12 weeks of daily capsinoids led to a decrease in body fat percentage and reduced appetite ratings, with participants unconsciously eating fewer calories​bmcobes.biomedcentral.com. Capsaicin works by activating brown fat (increasing fat burning) and stimulating release of catecholamines, which blunt hunger. While 20 mg of cayenne extract will contain a few milligrams of capsaicinoids, it can still cause a gentle metabolism boost and a bit of satiety. Additionally, capsaicin has been noted to improve circulation and endorphin release, which some users experience as a slight mood lift or increased energy after ingestion (hence the nickname “exercise in a pill” for its effect on metabolism​mdpi.com). In summary, cayenne/capsaicin contributes a thermogenic kick: helping the body burn a few more calories and potentially making it easier to adhere to a calorie-controlled diet by curbing appetite. This complements the other ingredients’ mechanisms, rounding out the formula’s multifaceted approach to weight management.

Primary Study

Inulin is a type of soluble fiber derived from plants like chicory root, asparagus, and garlic. It serves as a prebiotic, feeding beneficial gut bacteria and supporting digestive health. Inulin also helps in slowing digestion, promoting a feeling of fullness, and potentially aiding in weight management.

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